αKG-mediated carnitine synthesis drives DNA repair via histone acetylation
Apoorva Uboveja, Baixue Yang, Raquel Buj, Amandine Amalric, Hui Wang, Naveen Kumar Tangudu, Aidan R. Cole, Julie A. Disharoon, Richard S. Fang, Evan Levasseur, Miho Naruse, Zhentai Huang, Emily Megill, Daniel S. Kantner, Adam Chatoff, Hafsah Ahmad, Mariola M. Marcinkiewicz, Sarah Graff, Ellen De Pieri, Andrea Andress Huacachino, Frank P. Vendetti, Jeff Danielson, Erika S. Dahl, Jennifer L. Pennise, Esther Elishaev, Alison Jaccard, Lauren Borho, Miriam D. Post, Kristine Cooper, Francesmary Modugno, Nadine Hempel, Wayne Stallaert, Christopher J. Bakkenist, Simone Sidoli, Kathryn E. Wellen, Benjamin G. Bitler, David T. Long, Nathaniel W. Snyder, Katherine M. Aird
Anatoly Kulikov, Simon Storz, Josua D. SchÀr, Martin Sandfuchs, Ramona Wolf, Florence BerterottiÚre, Christoph Hellings, Andreas Wallraff, Renato Renner
Four ppm measurement of the antihydrogen ground-state hyperfine splitting
R. Akbari, L. O. de Araujo Azevedo, C. J. Baker, W. Bertsche, N. M. Bhatt, G. Bonomi, A. Capra, I. Carli, C. L. Cesar, M. Charlton, A. Cridland Mathad, A. Del Vincio, D. Duque Quiceno, S. Eriksson, A. Evans, J. Fajans, T. Friesen, M. C. Fujiwara, L. M. Golino, M. B. Gomes Gonçalves, J. S. Hangst, M. E. Hayden, P. Heidari, D. Hodgkinson, C. A. Isaac, S. A. Jones, S. Jonsell, N. Madsen, V. R. Marshall, J. T. K. McKenna, T. Momose, J. Nauta, A. N. Oliveira, A. Powell, C. Ă. Rasmussen, T. Robertson-Brown, F. Robicheaux, R. L. Sacramento, E. Sarid, J. Schoonwater, D. M. Silveira, J. Singh, G. Smith, C. So, S. Stracka, J. Suh, A. G. Swadling, T. D. Tharp, K. A. Thompson, R. I. Thompson, E. Thorpe-Woods, A. J. Uribe Jimenez, M. Urioni, D. P. van de Werf, S. G. Wilson, P. Woosaree, J. S. Wurtele, , C. L. Cesar, A. Del Vincio, D. P. van de Werf
Mechanism of age-related accumulation of mtDNA mutations in human blood
Rahul Gupta, Timothy J. Durham, Grant Chau, Masahiro Kanai, Md Mesbah Uddin, Wenhan Lu, M. Austin Argentieri, Konrad J. Karczewski, Daniel Howrigan, Pradeep Natarajan, Wei Zhou, Benjamin M. Neale, Vamsi K. Mootha
Human haematopoietic stem cells remember inflammatory stress
Andy G. X. Zeng, Murtaza S. Nagree, Niels Asger Jakobsen, Sayyam Shah, Angelica Varesi, Jasmine Ryu Won Kang, Alex Murison, Jin-Gyu Cheong, Sven Turkalj, Xuan Zhang, Felix A. Radtke, Tsega-Ab Abera, Isabel N. X. Lim, Liqing Jin, Joana AraĂșjo, Alicia G. Aguilar-Navarro, Darrien Parris, Jessica McLeod, Hyerin Kim, Ho Seok Lee, Lin Zhang, Mason Boulanger, Elyssa Bader, Elias Gbeha, Christopher N. Parkhurst, Elvin Wagenblast, Eugenia Flores-Figueroa, Bo Wang, Gregory W. Schwartz, Leonard D. Shultz, Anna S. Nam, H. Leighton Grimes, Steven Z. Josefowicz, Philip Awadalla, Paresh Vyas, John E. Dick, Stephanie Z. Xie
ÎČ-Arrestin condensates regulate G-protein-coupled receptor function
Preston J. Anderson, Peng Xiao, Ya-Ni Zhong, Adam N. Kaakati, Juliana Alfonso-DeSouza, Alejandra Patino, Andrew Ahn, Chanpreet Jassal, Tianyao Zhang, Chao Zhang, Kexin Yu, Lei Qi, Wei Ding, Samuel Liu, Biswaranjan Pani, Athmika Krishnan, Oscar Chen, Joseph Strawn, Joshua C. Snyder, Jin-Peng Sun, Sudarshan Rajagopal
Universal transcriptomic hallmarks of mammalian ageing and mortality
Alexander Tyshkovskiy, Daria Kholdina, Maria Davitadze, Adrian MoliĂšre, Alibek Moldakozhayev, Yoshiyasu Tongu, Tomoko Kasahara, Dmitrii Glubokov, Alec Eames, Leonid M. Kats, Anastasiya Vladimirova, Kejun Ying, Hanna Liu, Bohan Zhang, Uma Khasanova, Mahdi Moqri, Jeremy M. Van Raamsdonk, David E. Harrison, Randy Strong, Takaaki Abe, Sergey E. Dmitriev, Vadim N. Gladyshev
Direct observation of the superallowed α-decay of 104Te
Ian Cox, Robert Grzywacz, T. T. King, K. P. Rykaczewski, S. Nishimura, R. Yokoyama, N. Fukuda, N. Kitamura, S. Go, C. Mazzocchi, J. M. Allmond, A. Augustyn, N. Braukman, P. Brionnet, A. Esmaylzadeh, J. Fischer, G. Garcia de Lorenzo, S. Hanai, D. Hoskins, N. Imai, K. Kolos, A. Korgul, B. Kreider, S. Michimasa, K. Nishio, V. Phong, T. J. Ruland, H. Sakurai, Y. Shimizu, A. Skruch, H. Suzuki, H. Takeda, Y. Togano, Z. Y. Xu, M. Yoshimoto
Redesigning algorithms to intervene on social norm misperceptions during a national election
William J. Brady, Meriel Doyle, Abdo Elnakouri, Eli J. Finkel, Joshua Conrad Jackson, Nour Kteily, Victoria Parker, Curtis Puryear, Trevor Spelman, Jacob Teeny, Mark Torres
As digital access expands rapidly among children worldwide, technology-facilitated child sexual exploitation and abuse (CSEA), including online grooming, sexual solicitation, non-consensual image sharing and sexual extortion, has emerged as urgent yet underexamined category of digital harms 1 . Despite growing policy attention to online safety, evidence remains limited, particularly in low- and middle-income countries, where most of the worldâs children live 2 . We analysed nationally representative survey data from 11,912 children aged 12â17 years across 12 countries in eastern and southern Africa and Southeast Asia, collected through the Disrupting Harm project in 2020â2021. We found that one in six internet-using children experienced at least one form of technology-facilitated CSEA, equivalent to over 10 million children. Despite this scale, many experiences went undisclosed, pointing to disclosure as a critical pathway for protection in the digital age. When children did disclose, they relied primarily on informal channels, especially friends, rather than formal reporting mechanisms such as police or helplines. Using Bayesian hierarchical models accounting for cross-country heterogeneity, we find that older children were less likely to disclose, whereas enabling parental mediation of online activities and childrenâs knowledge of where to seek help after sexual harassment or assault were associated with higher rates of disclosure. These findings provide population-level evidence to inform prevention and response across low- and middle-income countries, where coordinated action by policymakers, law enforcement and technology companies is urgently needed to protect all children.
Visualizing a lung neutrophil-platelet immunothrombosis cascade during sepsis in mice
Luke Brown, Jared Schlechte, Mahum Rashid, Yuefei Lou, Angela P. Nguyen, Mortaza F. Hassanabad, Carlos H. Hiroki, Eduardo Cobo, Morley D. Hollenberg, Braeden McDonald, Bryan G. Yipp
Disruptive effects of brief radiofrequency noise exposure on migratory bat navigation
Oliver Lindecke, William T. Schneider, Viesturs Vintulis, Nicole Jordan, Fyodor Cellarius, Lara C. Marggraf, Jaclyn Niehues, Valts Jaunzemis, Oskars KeiĆĄs, Richard A. Holland
Hematite is a mineralogical marker of ancient climate change on Mars
Marek Szczerba, Tanya S. Peretyazhko, Elizabeth B. Rampe, Thomas F. Bristow, Benjamin M. Tutolo, Douglas W. Ming, David T. Vaniman, Richard V. Morris, Silas J. Ralston, Nikole C. Haney, Bum Soo Kim, David F. Blake, Steve J. Chipera, Robert T. Downs, Robert M. Hazen, Shaunna M. Morrison, Allan H. Treiman, Albert S. Yen, Valerie M. Tu, Michael T. Thorpe, Cherie N. Achilles, David J. Des Marais, John P. Grotzinger, Nicholas Castle, Patricia C. Craig, Elisabeth M. Hausrath, Sarah L. Simpson
Dependence of catalytic properties of strongly supported platinum clusters with atom counts
Chyan Kyung Song, Junhyeok Jung, Shyama Charan Mandal, Sungsu Kang, Tae Yong Kim, Chan Kim, Gyeongrok Jang, Hyungjoo Kim, Younhwa Kim, Kyung Rok Lee, Ji Soo Kim, Junjie Chen, Yongmin Kim, Chang Won Yoon, Thomas F. Jaramillo, Matteo Cargnello, Frank Abild-Pedersen, Jungwon Park
Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditions
Clivia Lisowski, Michael Quetting, Daniela Klaus, Lisa Lazarevski, Lea Seep, Maximilian Germer, Jian Li, Inge MĂŒller, Daniel Zuniga, Wolfgang Fiedler, Dina K. N. Dechmann, Kasper Thorup, Jan Hasenauer, Lars Fester, Stefanie Kuerten, Michael Farle, Ulf Wiedwald, Martin Wikelski, Christian Kurts
Importance of elephants for dung beetle biodiversity and ecosystem functions
Finote Gijsman, Ciara M. Nutter, Fathiya M. Khamis, Fidelis L. O. Ombura, Matthew C. Hutchinson, Todd M. Palmer, Jacob R. Goheen, Scott E. Miller, Robert M. Pringle
Selective autophagy fine-tunes plant immunity to promote cell survival during viral infection
Marion Clavel, Anita Bianchi, Roksolana Kobylinska, Roan Groh, Xi Zhang, Juncai Ma, Ranjith K. Papareddy, Nenad Grujic, Lorenzo Picchianti, Ethan Stewart, Michael Schutzbier, Karel Stejskal, Juan Carlos de la Concepcion, Victor Sanchez de Medina Hernandez, Yoav Voichek, Pieter Clauw, Joanna Gunis, Gerhard Durnberger, Jens Christian Muelders, Annett Grimm, Arthur Sedivy, Mathieu Erhardt, Victoria Vyboishchikov, Peng Gao, Esther Lechner, Emilie Vantard, Thomas Potuschak, Jakub Jez, Elisabeth Roitinger, Pascal Genschik, Byung-Ho Kang, Yasin Dagdas
Science abstract < 200 char.: Not a research
article
An Arctic community on the climate front lines My World is Melting Line Nagell YlvisÄker, translated by Kelsey Camacho University of Wisconsin Press, 2026. 190 pp.
Science abstract < 200 char.: Not a research
article
In Science Journals
Keith T. Smith, Angela Hessler, Jack Huang, Melissa L. Norton, Phil Szuromi, Priscilla N. Kelly, Bianca Lopez, Wei Wong, Ian S. Osborne, Di Jiang, Sarah H. Ross, Unnati Sonawala, Madeleine Seale, Michael A. Funk, Marc S. Lavine, Sacha Vignieri, Claire Olingy
Science abstract < 200 char.: Not a research
article
Galileo's Fame: Science, Credibility, and Memory in the Seventeenth Century Galileo's Fame: Science, Credibility, and Memory in the Seventeenth Century Anna-Luna Post University of Pittsburgh Press, 2025, 280 pp.
Throughout the world, peer review serves as the cornerstone of the scientific enterprise, providing rigorous quality control and building the confidence that underpins progress for both science and society. Without such a robust process, scientists and the general public would rapidly lose the ability to distinguish groundbreaking advances from noise, which undermines policy decisions, research translation, and most importantly, public trust in science. Sadly, that is exactly what has been happening in Australia.
Nature Human Behaviour
Generic title: Not a research article
The healing power of nature reduces stress, anxiety and depression
Thalamic oscillations distinguish natural states of consciousness in humans
Aditya Chowdhury, Xiongbo Wu, Tara Beilner, Thomas Schreiner, Thomas Koeglsperger, Jan-Hinnerk Mehrkens, Jan Remi, Christian Vollmar, Elisabeth Kaufmann, Tobias Staudigl
Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of estrogen receptor-positive breast cancer brain metastases
Morgan S. Fox, Jenny A. Jaramillo-GĂłmez, R. Alejandro Marquez-Ortiz, Karen L. F. Alvarez-Eraso, Maria J. Contreras-ZĂĄrate, Trinh C. Pham, Elaina N. Barela, Stella N. Koliavas, Peter Kabos, Natalie J. Serkova, Carol A. Sartorius, Elizabeth A. Wellberg, Diana M. Cittelly
A lipidomics roadmap: from basic research to societal challenges
Maria Fedorova, Anne K. Bendt, Justine Bertrand-Michel, Oliver Fiehn, Joanna Godzien, Laura Goracci, Florian Gruber, Xue Li Guan, Xianlin Han, Michal HolÄapek, Julia Kuligowski, Peter J. Meikle, Palina Nepachalovich, Valerie B. OâDonnell, Matej OreĆĄiÄ, Sider Penkov, SnjezÌana PetrovicÌ, Anton Potapov, Patricia Prabutzki, Laura Righetti, Tatjana Ruskovska, Andrej Shevchenko, Kai Simons, Corinne M. Spickett, Olga Vvedenskaya, Jennifer Watts, Markus R. Wenk, Michael Witting, Yu Xia, Baoru Yang, Maria RosĂĄrio Domingues
GWAS of extended prescription analgesic use identifies genetic loci in chronic pain
Charli E. Harlow, Emeka Uzochukwu, Hazel A. Fernando, Charles E. Mordaunt, Jordan M. Hughey, John D. Eicher, Lara Robinson, Nicholas Bowker, Laurence Howe, Jimmy Liu, Adrian Cortes, Paul Wilson, Usha Gungabissoon, Victoria S. Benson, Anthony Nash, Gareth Young, Laura Addis, Chun-Fang Xu, Caleb Webber, Jonathan Davitte, M. Zameel Cader
Population-scale chemical response revealed by a barcoded yeast collection
Abhishek Dutta, Marion Garin, Victor Loegler, Gauthier Brach, Anne Friedrich, Mami Yoshimura, Hiroyuki Hirano, Hiroyuki Osada, Charles Boone, Yoko Yashiroda, Jing Hou, Joseph Schacherer
Fusion-positive rhabdomyosarcoma oncofusions share a common interactome
S. P. Zimmerman, C. D. Delaney, B. K. Lau, L. B. DeGraw, G. H. Rupprecht, M. J. A. Groot Koerkamp, T. de Souza, J. Drost, R. A. Schoot, M. T. Meister, J. F. Shern, L. M. Wagner, G. G. Wang, K. C. Wood, C. M. Linardic, C. M. Counter
Revealing ultrafast proton-transfer-mediated autoionization as a source of low-energy electrons in hydrogen-bonded systems
Wael Iskandar, Yi-Siang Wang, Victor A. Suarez, Matthew C. Rohan, Kirk A. Larsen, James Zhong Manis, Travis Severt, Joshua B. Williams, Itzik Ben-Itzhak, Thomas M. Orlando, Joshua S. Kretchmer, Daniel S. Slaughter, Thorsten Weber
Structure of ergosteryl-aspartate synthase reveals how an entrapped tRNA is used like a prosthetic swinging arm in the synthesis of aminoacylated sterols
Author Correction: A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells
Xue Li, Quan Jiang, Guiyu Song, Mahsa Nouri Barkestani, Qianxun Wang, Shaoxun Wang, Matthew Fan, Caodi Fang, Bo Jiang, Justin Johnson, Arnar Geirsson, George Tellides, Jordan S. Pober, Dan Jane-wit
REPLY TO: âDaylight Saving Time and MortalityâProceed with Caution âin response to âDaylight saving time affects European mortality patternsâ by Levy et al
Human forebrain neural synchronization and entrainment to breathing during wakefulness, sleep, and external mechanical ventilation
Md Rakibul Mowla, Ariane E. Rhone, Sukhbinder Kumar, Christopher K. Kovach, Junjie V. Liu, Aubrey C. Chan, Hiroto Kawasaki, Rashmi N. Mueller, Justin D. Kuhn, Ryan T. Frede, Michael A. Ciliberto, Theresa M. Czech, Sreenath Thati Ganganna, James W. Owens, Ania K. Dabrowski, Brittany N. Sprigg, Mark A. Granner, Kristina Simonyan, Kirill V. Nourski, Bryan M. Krause, Matthew I. Banks, Matthew A. Howard, Paul W. Davenport, Kyle T. S. Pattinson, George B. Richerson, John A. Wemmie, Brian J. Dlouhy
Paired DNA and RNA sequencing uncovers common and rare variation regulating human retinal gene expression
Jacob Sampson, Ayellet V. SegrĂš, Kinga M. Bujakowska, Simon J. Clark, Paul N. Bishop, Steve Haynes, Diana Baralle, Jospin Al-Deek, Stacey Holden, Beverley Anderson, Andrew Hayes, Rahmat A. Kemal, Huw B. Thomas, Raymond T. OâKeefe, Siddharth Banka, Graeme C. Black, Panagiotis I. Sergouniotis, Jamie M. Ellingford
Quantum beats of exciton-polarons in CsPbI3 perovskite nanocrystals
Artur V. Trifonov, Mikhail O. Nestoklon, M. Alex Hollberg, Stefan Grisard, Dennis Kudlacik, Elena V. Kolobkova, Maria S. Kuznetsova, Serguei V. Goupalov, Jan M. Kaspari, Doris E. Reiter, Dmitri R. Yakovlev, Manfred Bayer, Ilya A. Akimov
Sang Hwa Park, Nicolas Leconte, Huseung Lee, Jeonglyul Kim, Byunghyun Kim, Ayoung Yuk, Daesung Park, Jiyun Chang, Feng Ping Li, Kenji Watanabe, Takashi Taniguchi, Hyeonsik Cheong, Hyobin Yoo, Jeil Jung, Sang Mo Yang
Very low-carbohydrate ketogenic diet in treatment-naĂŻve women with endometrial cancer and overweight: a randomized feasibility study
Ezequiel Dantas, Katie C. Hootman, Jenna Moyer, Morgan Tomberlin, Katherine Curran, Bhavani Ramesh, Hannah Price, Jeshua Kim, Alex C. McPherson, Maurice A. Hurd, Yuan-Shan Zhu, Andrew J. Plodkowski, Erica Nagase, Anastasia Tsomides, Brandon M. Cuevas, M. Laura Martin, John Nguyen, Gabrielle Bennetti, Gissell Botero Rodriguez, Kaity Chang, Marissa Mezzancello, Ginger J. Gardner, Vance Broach, Jennifer J. Mueller, Yukio Sonoda, Oliver Zivanovic, Mario M. Leitao, Alexia Iasonos, Krysten Soldan, Karen Carthew, Vania Hom, Francis N. Villamater, Rema Rao Chaari, Kathryn Gorski, Michael Sigouros, Carol Aghajanian, Olivier Elemento, Lewis C. Cantley, Benjamin D. Hopkins, Britta Weigelt, Lora H. Ellenson, Kari Hacker, Nadeem R. Abu-Rustum, Vicky Makker, Marcus D. Goncalves
Structural basis of signal peptide recognition by the signal peptidase complex
A. Manuel Liaci, Dimitrios Vismpas, Lisbeth R. KjÞlbye, Ioannis Skalidis, Gilberto P. Pereira, Adrian Fujiet Koh, Mariska Gröllers-Mulderij, Abhay Kotecha, Paulo C. T. Souza, Friedrich Förster
An artefact-resilient wide bandwidth bidirectional graphene neural interface
MichaĆ Prokop, MartĂn Esparza-Iaizzo, Eduard Masvidal-Codina, Xavi Illa, Neela K. Codadu, Daman Rathore, Nicola Ria, Kostas Kostarelos, Elena del Corro, Ramon Garcia-Cortadella, Rob C. Wykes, Anton GuimerĂ -Brunet, Jose A. Garrido
Small extracellular vesicle signaling and mitochondrial transfer reprogram T helper cell function in human asthma
Kenneth P. Hough, Jennifer L. Trevor, Shaheer Ahmad, Yong Wang, Balu K. Chacko, Kayla F. Goliwas, John G. Strenkowski, Yuelong Liu, Joanna I. Nowak, Eugene J. Becker Jr, Young-il Kim, Renita Holmes, Nathaniel B. Bone, Shia Vang, Alexandra Pritchard, Jay Chin, Sandeep Bodduluri, Veena B. Antony, Sultan Tousif, Mohammad Athar, Diptiman Chanda, Kasturi Mitra, Jaroslaw W. Zmijewski, Jianhua Zhang, Steven R. Duncan, Victor J. Thannickal, Susanne Gabrielsson, Victor M. Darley-Usmar, Jessy S. Deshane
Durvalumab plus anlotinib versus durvalumab alone as maintenance treatment in extensive-stage small-cell lung cancer (DURABLE): a multicenter, randomized, phase II trial and biomarker analysis
Bo Zhang, Runbo Zhong, Chunlei Shi, Tianqing Chu, Wei Zhang, Huimin Wang, Xin Gan, Zhihong Zhang, Changbin Zhu, Xing Li, Wenzhong Su, Juan Li, Yanwei Zhang, Baohui Han, Hua Zhong
Long-term comparative analysis of AAV9-mediated gene replacement therapies for spinal muscular atrophy in mice
Xiupeng Chen, Qing Xie, Sarah J. Nath, Mojiao Tang, Hong Ma, Yasemin ĂzgĂŒr GĂŒnes, Tapan Sharma, Hao Liu, Mengtian Cui, Ailing Du, Mengjia Lu, Sophia Y. Liu, Boonying Wassamon, Mengyao Xu, Joseph Yunxi Wu, Qin Su, Timothy P. Fitzgibbons, Jinghua Liu, Fang Wan, Veena Kumanan, Ran He, Yijie Ma, Jun Yang, Heather L. Gray-Edwards, Thomas L. Gallagher, Phillip W. L. Tai, Guangping Gao, Jun Xie
Large-scale investigation for antimicrobial activity reveals newly-identified defensive species across the healthy skin microbiome
Uyen Thy Nguyen, Rauf Salamzade, Shelby Sandstrom, Mary Hannah Swaney, Elizabeth C. Townsend, Sherrie Y. Wu, J. Z. Alex Cheong, Joseph A. Sardina, Isabelle Ludwikoski, Mackinnley Rybolt, Hanxiao Wan, Caitlin M. Carlson, Jordana Ferro, Owen McArthur, Won Se Suh, Robert Zarnowski, David R. Andes, Cameron R. Currie, Lindsay R. Kalan
Deciphering cytokine-driven ADP-ribosylation signaling networks via Af1521-based mass spectrometry analysis of labile Glu/Asp-linkages
Sara C. Buch-Larsen, Ivo A. Hendriks, Kyuto Tashiro, Jonas D. Elsborg, Sergey Y. Vakhrushev, Jesper V. Olsen, Bernhard LĂŒscher, Glen Liszczak, Ivan Ahel, Michael L. Nielsen
Dairy cows infected with influenza A(H5N1) reveals low infectious dose and transmission barriers
Carolyn Lee, Natalie N. Tarbuck, Hannah J. Cochran, Bryant M. Foreman, Patricia Boley, Saroj Khatiwada, Alok Dhakal, Khadijat O. Adefaye, Jennifer Schrock, Mohammad Jawad Jahid, Thamonpan Laocharoensuk, Raksha Suresh, Olaitan Shekoni, Erika Stevens, Sara Dolatyabi, Christina Sanders, Elizabeth Ohl, Devra Huey, Juliette Hanson, Kara Corps, Renukaradhya Gourapura, Richard J. Webby, Cody J. Warren, Scott P. Kenney, Andrew S. Bowman
Tumor sialylation regulates G-CSF stability and promotes neutrophil-mediated immunosuppression in breast cancer
Stefan Mereiter, Gustav Jonsson, Tiago Oliveira, Ingrid-Judith Garberis, Johannes Helm, Markus Abeln, Ann-Kristin Jochum, Wolfram Jochum, Max J. Kellner, Marek Feith, Vanessa Tkalec, Karolina Wasilewska, Jie Jiao, David Hoffmann, Lukas Emsenhuber, Felix Holstein, Anna C. Obenauf, Guido Kroemer, Magali Lacroix-Triki, Omar Hasan Ali, Lukas Flatz, Rita Gerardy-Schahn, Anja MĂŒnster-KĂŒhnel, Johannes Stadlmann, Laurence Zitvogel, Josef M. Penninger
Ecological and genomic signatures of the convergent evolution of planktivory in fossil and living reef fishes over deep time
Aintzane Santaquiteria, Dahiana Arcila, Giorgio Carnevale, Melissa Rincon-Sandoval, Fernando Melendez-Vazquez, William T. White, Carole C. Baldwin, Mark W. Westneat, Guillermo OrtĂ, James C. Tyler, Ricardo Betancur-R
Context-specific life cycle emissions pathways for EU buildings and construction
Nicolas Alaux, Nicolas Bechstedt, Xiaoyang Zhong, Alessio Mastrucci, Delphine Ramon, Dominik Steinberger-Maierhofer, Karen Allacker, Alexander Passer, Martin Röck
Open-channel block of human TRPV6 by polyamine spermine
Arthur Neuberger, Irina I. Veretenenko, Alexey Shalygin, Yury A. Trofimov, Thomas Gudermann, Vladimir Chubanov, Roman G. Efremov, Alexander I. Sobolevsky
Pneumococcus uses COMMD2 to alter host cellular immunity
Michael G. Connor, Lisa Sanchez, Christine Chevalier, Tiphaine M. N. Camarasa, Filipe Carvalho, Matthew J. G. Eldridge, Thibault Chaze, Mariette Matondo, Esma Karkeni, Sara Dufour, Francis Impens, Sebastian Baumgarten, Jost Enninga, Melanie A. Hamon
Extensive variation between chromosomes of North American and European hop
Sandip Mallikarjun Kale, Heidrun Gundlach, Oliver Gericke, Nadia Kamal, Aldo Almeida, Nicholi Pitra, Nicholas Price, Georg Haberer, Thomas Lux, Flavia Krsticevic, Oliver Kemp, Louise de Bang, Axel Himmelbach, Sudharsan Padmarasu, Mark-Timothy Rabanus-Wallace, Lucie HorĂĄkovĂĄ, VĂĄclav BaÄovskĂœ, Kasper Nielsen, Nanna Bjarnholt, Nikola Micic, Isabella Kruse-Andersen, Birger Lindberg MĂžller, Christian Janfelt, Birgitte Skadhauge, Paul D. Matthews, Klaus F. X. Mayer, Nils Stein, Martin Mascher, Manuel Spannagl, Alexander Feiner, Ilka Braumann
Benchmarking genome choice in functional genomics analyses
Juan F. Macias-Velasco, Xiaoyu Zhuo, Chad Tomlinson, Eddie A. Belter, Milinn Kremitzki, Derek Albracht, Tina Lindsay, Xiaoyun Xing, Nina Tekkey, Wenjin Zhang, John E. Garza, Zheng Xu, Zilan Xin, Qichen Fu, Heather A. Lawson, Nathan O. Stitziel, Robert S. Fulton, Daofeng Li, , Ting Wang
Near-infrared fluorescence imaging-guided surgery using cRGD-ZW800 to improve surgical resection margins in oral cancer: a phase I/II feasibility trial
B. E. Zweedijk, L. J. Lauwerends, H. A. Galema, D. J. Robinson, H. S. de Bruijn, H. Abbasi, T. L. March, A. R. P. M. Valentijn, M. Pool, H. Mast, B. P. Jonker, J. A. U. Hardillo, D. Monserez, A. Sewnaik, S. Koljenovic, C. Verhoef, R. J. Baatenburg de Jong, J. V. Frangioni, S. A. Koppes, D. E. Hilling, A. L. Vahrmeijer, S. Keereweer
TAK1 drives inflammatory fibroblast acquisition and shapes myocardial infarction responses in male mice
Daniel C. Nguyen, Jonah K. Stephan, Lianay Gutierrez Luque, Robert E. Brainard, Kenneth R. Brittian, Collin K. Wells, Madison S. Teer, Yania Martinez-Ondaro, Kara R. Gouwens, Danielle T. Little, Yibing Nong, Nolan L. Boyd, Ashok Kumar, Steven P. Jones, Richa Singhal, Jason Hellmann, Marcin Wysoczynski, Bradford G. Hill
Comparative analysis of the cellular landscape in mammalian striatum
Gozde Buyukkahraman, Emre Caglayan, Stephen G. Hörpel, Yaqiang Zhang, Ine A. van Tussenbroek, Carlos G. Orozco, Emily Oh, William D. Hopkins, Chet C. Sherwood, Todd F. Roberts, Sonja C. Vernes, Genevieve Konopka
Intracellular potassium levels orchestrate circadian rhythmicity and cell division
Sergio Gil RodrĂguez, Louise L. Hansen, Olivia J. P. Fraser, Yen Peng Chew, Rebecca K. Spangler, Ellen GrĂŒnewald, Andrew D. Beale, Beverley M. Rabbitts, Alessandra Stangherlin, John S. OâNeill, Carrie L. Partch, Priya Crosby, Gerben van Ooijen
TRIM21 facilitates inflammasome assembly and contributes to autoinflammatory disease
Jessica Carriere, Chawon Yun, Sonal Khare, Sana Ismaeel, Elisabeth JĂ€ger, Vinicius Dantas Martins, Kaiden A. Sims, Lan H. Chu, Huyen Nguyen, Lucia de Almeida, Janset Onyuru, Justin Ruiz, Hemisha Khatri, Savita Devi, Jae Jin Chae, Daniel L. Kastner, Lori Broderick, Hal M. Hoffman, Andrea Dorfleutner, Christian Stehlik
Predictive acoustical processing in human cortical layers
Lonike K. Faes, Isma Zulfiqar, Luca Vizioli, Zidan Yu, Yuan-hao Wu, Jiyun N. Shin, Martijn A. Cloos, Ryszard Auksztulewicz, Lucia Melloni, Kamil Uludag, Essa Yacoub, Federico De Martino
qChIP-MS reveals the local chromatin composition by label-free quantitative proteomics
Wai Khang Yong, Nurkaiyisah Zaal Anuar, Zi Wayne Sin, Elayne Su Ru Tan, Grishma Rane, Xiaoman Shao, Chai Yeen Goh, Vartika Khanchandani, Vivian L. S. Kuan, Peh Fern Ong, Maya Jeitany, H. Phillip Koeffler, Lih-Wen Deng, Oliver Dreesen, Takaomi Sanda, Dennis Kappei
SNAP-23 mediated vesicular trafficking in oligodendrocytes is necessary to maintain adult myelin integrity in mice
Chun Hin Chow, Mengjia Huang, Aryan Regmi, Jayant Rai, Hidekiyo Harada, Sarah Eide, Hong-Shuo Sun, Zhong-Ping Feng, Philippe P. Monnier, Kenichi Okamoto, Liang Zhang, Olga L. Rojas, Shuzo Sugita
RNAs anchoring replication complex control initiation and firing of DNA replication
Simone Ummarino, Larysa Poluben, Alexander K. Ebralidze, Ida Autiero, Lucrezia Rinaldi, Theodore Paniza, Madhura Deshpande, Nicholas H. Mandel, Johnathan D. Lee, Yanzhou Zhang, Mahmoud A. Bassal, Bogdan Budnik, Bon Q. Trinh, Steven P. Balk, Robert Flaumenhaft, Jeannine Gerhardt, Sergei M. Mirkin, Daniel G. Tenen, Annalisa Di Ruscio
Genetic variants affect diurnal glucose levels throughout the day
Nasa Sinnott-Armstrong, Satu Strausz, Lea Urpa, Erik Abner, Josephine P. Johnson, Jesse Valliere, Teele Palumaa, , , , Priit Palta, Hassan S. Dashti, Kyong-Mi Chang, Marijana Vujkovic, Mark Daly, Jonathan K. Pritchard, Richa Saxena, Samuel E. Jones, Hanna M. Ollila
ZNF274 constrains lineage plasticity and drives intrinsic resistance to CDK7 inhibitors in pancreatic cancer
Jessica E. Gianopulos, Aidan Schutter, Stephanie Dobersch, Adrianne Wallace-Povirk, Sophie E. Kogut, Andrea Doak, Pritha Chanana, Sabrina Ge, Luke Mangino, Naomi Yamamoto, Liberalis D. Boila, Monica Padilla-Galvez, Justin Hui, Nicole Rhoads, Robert J. Gifford, Kevin J. Cheung, Daniel Blanco-Melo, Faiyaz Notta, Sita Kugel
Neighbouring group participation hindered by force as a molecular design for covalent catch bonds
Soumabrata Majumdar, Diederik van Luijk, Martijn M. van Galen, Pascal Vermeeren, Trevor A. Hamlin, F. Matthias Bickelhaupt, Joris H. B. Sprakel, Rolf A. T. M. van Benthem, Johan P. A. Heuts, Rint P. Sijbesma
Convergent and divergent brainâcognition development in early adolescence
Yapei Xie, Shaoshi Zhang, Csaba Orban, Leon Qi Rong Ooi, Ru Kong, Dorothea L. Floris, Xi-Nian Zuo, Elvisha Dhamala, Avram J. Holmes, Lucina Q. Uddin, Thomas E. Nichols, Adriana Di Martino, B. T. Thomas Yeo
Long-term temporal stability of circulating proteins in older adults
Hulda K. Ingvarsdottir, Heida Bjarnadottir, Thomas R. Austin, Elisabet A. Frick, Eva Jacobsen, Kari Arnarson, Nancy Finkel, Joseph J. Loureiro, Lenore J. Launer, Joshua C. Bis, Thor Aspelund, Valur Emilsson, Michelle C. Odden, Arnar Palsson, Vilmundur Gudnason, Valborg Gudmundsdottir
An X-linked sex determination mechanism in cannabis and hop
Sarah B. Carey, Philip C. Bentz, John T. Lovell, Laramie M. Akozbek, Zachary A. Myers, Walid Korani, Joshua S. Havill, Lillian Padgitt-Cobb, Ryan C. Lynch, Nicholas Allsing, Jack Mangels, Zachary Stansell, George M. Stack, Tyler Gordon, Austin Osmanski, Katherine A. Easterling, Leonardo R. Orozco, Zach E. Marcus, Haley Hale, Hannah McCoy, Zachary Meharg, Jane Grimwood, Lawrence B. Smart, Daniela Vergara, Rafael F. Guerrero, Nolan C. Kane, Rich Fletcher, John K. McKay, Todd P. Michael, Gary J. Muehlbauer, Josh Clevenger, Alex Harkess
Absolute quantification of enantiomeric purity of sorted carbon nanotubes by correlating hyperspectral fluorescence microscopy with ensemble chiroptical spectroscopy
Deep phenotyping of skin tissue remodeling in patients with systemic sclerosis treated with CD19-CAR T cells
Aleix Rius Rigau, Meilin Xu, Ziyuan Liu, Sara Chenguiti Fakhouri, Janina Auth, Panagiotis Garantziotis, Andrea Zoli, Manoj Kumar Selvaraju, Maria Gabriella Raimondo, Carlo Tur, Tim Filla, Paula Gehringer, Markus Eckstein, Fabian MĂŒller, Armin Atzinger, Moritz Ronicke, Arif Ekici, Rafael Schmid, Andreas Wirsching, Melanie Hagen, Sebastian Böltz, Tobias Krickau, Raymund E. Horch, Carola Berking, Ricardo Grieshaber-Bouyer, Andreas Ramming, Pooja Gupta, Aline Bozec, Andreas Mackensen, Jörg HW Distler, Georg Schett, Yi-Nan Li, Christina Bergmann
Initial leukemic epigenomic state determines hypomethylating agent response
Aparna Gopal, Derek Tam, Franziska Mey, Diana Lin, Christina May, Jihong Jiang, Joshua Bridgers, Brett Caswell, Kieran OâNeill, Frederick S. Vizeacoumar, Mackenzie MacAuley, Emilie Haniak, Charles Craddock, Paresh Vyas, Luca Malcovati, Rena Buckstein, Michelle Moksa, Martin Hirst, Franco J. Vizeacoumar, Nadia Medvedev, Michael Heuser, Ryan J. Stubbins, Yu Deng, Aly Karsan
Chaperone-mediated autophagy is required for regulatory T cell function
Ranee Harrison, Floralba Gjergjova, Sandra Pelka, Adrian Macho-Gonzalez, Bhakti Chavda, Kristen Lindenau, Aiara Gazteluiturri Garcia, Rabia R. Khawaja, Jennifer T. Aguilan, Simone Sidoli, Susmita Kaushik, Yair Botbol, Ana Maria Cuervo, Fernando Macian
Pembrolizumab plus high-dose IL-2 in advanced clear cell renal cell carcinoma: six-year survival outcomes and molecular signatures from a phase 2 trial
Jeffrey S. Johnson, Justin W. Miller, Firas Hatoum, Michael J. Schell, Xiaoqing Yu, Gabriel Roman Souza, Sarah Mizelle, Keerthi Gullapalli, Adnan Fazili, Rohit Jain, Jonathan Chatzkel, Ling Cen, Jasreman Dhillon, Christopher Cubitt, Jiqiang Yao, Junmin Whiting, Jiannong Li, Jennifer Swank, Ghazal Jameel, Jingsong Zhang, Xuefeng Wang, Philippe E. Spiess, Mayer Fishman, Jad Chahoud
Coulombic control of charge transfer in radicals with quartet recycling luminescence
Lujo Matasovic, Petri Murto, Shilong Yu, Wenzhao Wang, James D. Green, Giacomo Londi, Weixuan Zeng, Laura Brown, William K. Myers, Lars van Turnhout, Konstantina Armadorou, Avik Bhanja, Sergiu Petrusca, David Beljonne, Yoann Olivier, Feng Li, Hugo Bronstein, Timothy J. H. Hele, Richard H. Friend, Sebastian Gorgon
Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy
Jaakko S. Tyrmi, Juha Karjalainen, Samvida S. Venkatesh, Clara Benoit-Pilven, Susanna M. LemmelÀ, SÞren Brunak, Bitten Aagaard, Mie T. Bruun, Christian Erikstrup, Henrik Ullum, Ole B. Pedersen, Karina Banasik, Erik SÞrensen, Christina Mikkelsen, Michael Schwinn, Arni Sturluson, Sisse R. Ostrowski, , , , Johannes Kettunen, Henriette Svarre Nielsen, Mette Nyegaard, David Westergaard, Thorunn Rafnar, Patrick Sulem, Kari Stefansson, Priit Palta, Triin Laisk, Taru Tukiainen, Cecilia M. Lindgren, Mark Daly, Aki S. Havulinna, Hannele M. Laivuori
Polyketide synthase-based controlled synthesis of polycyclopropanated fuel molecules
Kevin Yin, Alexander Landera, Namil Lee, Anthony T. Iavarone, Suzanne M. Kosina, Thomas D. Young, Kai Deng, Justin Baerwald, Yan Chen, Jennifer W. Gin, Riley Benedict, Yan Chiu, Ezechinyere Ukabiala, Methun Kamruzzaman, Kunal Poorey, Trent R. Northen, Christopher J. Petzold, Anthe George, Pablo Cruz-Morales, Qingyun Dan, Jay D. Keasling
Muscle mitochondria, function, mass, and quality of life in prostate cancer during androgen deprivation therapy
L. Caeiro, L. J. Anderson, A. Dash, D. J. Marcinek, H. L. Kerr, L. Paulsen, G. Miranda, S. Jaramillo Quiroz, T. Vaisar, M. A. Krueger, N. L. Acosta-Vega, S. A. Gharib, J. M. Garcia
Lifespan normative modeling of brain microstructure
Julio E. VillalĂłn-Reina, Alyssa H. Zhu, Leila Nabulsi, Sophia I. Thomopoulos, Clara A. Moreau, Yixue Feng, Tamoghna Chattopadhyay, Sebastian M. Benavidez, Leila Kushan, John P. John, Himanshu Joshi, Iyad Ba Gari, Katherine E. Lawrence, Talia M. Nir, Neda Jahanshad, Carrie E. Bearden, Seyed Mostafa Kia, Andre F. Marquand, , Paul M. Thompson
RBM20 isoform regulation by independent transcription start sites adapts alternative splicing in development and disease
Michael H. Radke, Victor Badillo Lisakowski, Stefan Meinke, Thiago Britto-Borges, Valentin Schneider-Lunitz, Oliver Hummel, Sebastiaan van Heesch, Jorge Ruiz Orera, Norbert Hubner, Henk Granzier, Christoph Dieterich, Michael Gotthardt
Loop extrusion by cohesin plays a role in enhancer-activated gene expression early in differentiation
Rosa J. Stolper, Felice H. Tsang, Emily Georgiades, Lars L. P. Hanssen, Edward A. J. Tunnacliffe, Damien J. Downes, Caroline L. Harrold, Jim R. Hughes, Robert A. Beagrie, Benjamin Davies, Mira T. Kassouf, Douglas R. Higgs
Author Correction: Kriging-based surrogate data-enriching artificial neural network prediction of strength and permeability of permeable cement-stabilized base
Experimental demonstration of corrugated nanolaminate films as reflective light sails
Matthew F. Campbell, Pawan Kumar, Jason Lynch, Ramon Gao, Adam Alfieri, John Brewer, Thomas J. Celenza, Mohsen Azadi, Michael D. Kelzenberg, Eric Stach, Aaswath P. Raman, Harry A. Atwater, Igor Bargatin, Deep Jariwala
PD-1 regulates latent effector differentiation of thymic cytotoxic CD8+ T cells
Zhiming Mao, Jacob B. Hirdler, Joanina K. Gicobi, Li Ding, Mark A. Maynes, Michelle A. Hsu, Emilia R. Dellacecca, Wenjing Zhang, Jacob J. Teske, Ying Li, Aubrey Y. Liew, Geoffrey Zhao, Adrian T. Ting, Virginia M. Shapiro, Fabrice Lucien-Matteoni, Henrique Borges da Silva, Daniel D. Billadeau, Haidong Dong
SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children
Qin Xu, Lihong Shi, , Liya Wang, Foo Cheung, Aparna Kotekar, Galina Koroleva, Elizabeth Rice, Richard Apps, Justin Lack, Craig Martens, Iyadh Douagi, Can Liu, Juraj Kabat, Hengameh Behzadpour, Lela Kardava, Tovah E. Markowitz, Margery Smelkinson, Kenneth B. Hoehn, Clarisa M. Buckner, Dominic P. Golec, Lorenza Bellusci, Gabrielle Grubbs, Sara Pourhashemi, Juanjie Tang, Asya Khleborodova, Martha Kirby, Rachel Sparks, Andrew J. Martins, John S. Tsang, Susan Moir, Surender Khurana, Pamela Mudd, Pamela L. Schwartzberg, Kalpana Manthiram
Dynamics of dislocation formations and their impacts on exsolution in Ru-doped perovskite oxide
Sungwook Choi, Younghwan Lim, Puspendu Guha, Hayoung Kim, Jaeseung Kim, Sungwon Kim, Ross Harder, Wonsuk Cha, Hoyoung Suh, Jinseok Ryu, Sungeun Yang, Ho-Il Ji, Deok-Hwang Kwon, Hyunjung Kim
Optimising DNA origami assembly by reducing off-target interactions
Ben Shirt-Ediss, Emanuela Torelli, Silvia Adriana Navarro, Hadeel Khamis, Ariel Kaplan, William Trewby, Juan Elezgaray, Nima Moradzadeh, Michael Haydell, Daniel Keppner, Michael Famulok, Kai Armstrong, Natalio Krasnogor
Distributional effects of marine conservation on coastal livelihoods in Eastern Indonesia
Duong Trung Le, Gabby N. Ahmadia, Indah Anggriyani Ratih, Kelly Claborn, Estradivari, Muhammad Erdi Lazuardi, Dariani Matualage, Phillip. M. Mohebalian, Hellen Nanlohy, Ni Kadek Sri Pusparini, Ranaivo Rasolofoson, Kezia E. Salosso, Natelda R. Timisela, Fitryanti Pakiding, Louise Glew, Michael B. Mascia, David Gill
Long-read deep sequencing reveals high rates of multilineage transmission and rapid viral population changes in acute HIV infection
James I. Mullins, Wenjie Deng, Elena E. Giorgi, Craig A. Magaret, Morgane Rolland, Tanmoy Bhattacharya, Dylan H. Westfall, Anna E. J. Yssel, Roger E. Bumgarner, Ben Murrell, Thumbi Ndungâu, Merlin L. Robb, Raabya Rossenkhan, Paul T. Edlefsen, Krista L. Dong, Lennie Chen, Asanda Gwashu-Nyangiwe, Hong Zhao, Ruwayhida Thebus, Nonkululeko Ndabambi, Bruna Galvao, Fredrick Sawe, Sorachai Nitayaphan, Talita York, David Matten, Hugh Murrell, Alec P. Pankow, Michal Juraska, James Ludwig, John Hural, Myron S. Cohen, Lawrence Corey, M. Juliana McElrath, Peter B. Gilbert, Carolyn Williamson
Correlating solvation shell dynamics and ion transport in highly ordered nanoporous polymers
Ranadeb Ball, Christopher W. Johnson, Lizhu Zhang, Rebecca N. Hopkins, Junkyu Hwang, Karen I. Winey, Amish J. Patel, Chinedum O. Osuji, Jessica M. Anna
The history of civil rights legislation offers a window into how American democracy codified social justice over time, and whether this process unfolded gradually or through punctuated shifts. Sixty years after the civil rights movement, we apply natural language processing to legislative archives to track how civil rights has evolved as a policy domain. We show that civil rights legislation has become more common, but also has diverged by party. Divergence accelerated during the early 1990s and mid-2010sâthe latter coinciding with the rise of the Black Lives Matter movement and driven by a surge in sponsorship among racial minority Democrats in Congress. Topic modeling reveals that divergence is concentrated in legislation concerning racial minorities, women, and LGBTQ+ populations, while attention to older adults and people with disabilities has declined across both parties. Our findings offer potential insights into party divergence, race and ethnicity politics, and collective action tipping points.
Critical misalignments in climate pledges reveal imbalanced sustainable development pathways
Francesca Larosa, Lamyae A. Rhomrassi, Sergio Hoyas, J. Alberto Conejero, Javier Garcia-Martinez, Fermin Mallor, Francesco Fuso Nerini, Ricardo Vinuesa
We explore the integration of climate action and Sustainable Development Goals (SDGs) in the first two submissions of nationally determined contributions (NDCs) using an AI-based, human-validated framework. Our goal is to provide ex-ante evidence relevant to assessing policy adequacy. We find disparities in topics of interest with high-income countries emphasizing systemic challenges (health, SDG3) and low-income nations prioritizing the water-energy-food nexus (SDGs 6-7-12) and natural resource management (SDG15). We discuss what these diverging development trajectories imply for the Paris Agreement and the 2030 Agenda for sustainable development in terms of global inequality, sustainable finance flows and multilateral governance.
Science Advances
GPT-4o mini: Non-social science research article
A plant immune receptor mediates tritrophic interactions by linking caterpillar detection to predator recruitment
Natalia GuayazĂĄn Palacios, Patrick Grof-Tisza, Brian Behnken, Carla Marques Arce, Di Wu, Antonio F. Chaparro, Benjamin D. Sheppard, Eric A. Schmelz, Ted C. J. Turlings, Betty Benrey, Adam D. Steinbrenner
Distinct properties of plastic-derived submicrometer particles from smoldering burning
Lin Kong, Hongru Shen, Xing Wang, Michael A. R. Tawadrous, Emily R. Halpern, Qiaorong Xie, Alexander Laskin, Kin Fai Ho, Bonnie M. Hamilton, Alex K. Y. Lee, Man Nin Chan, Arthur W. H. Chan
Lotus japonicus VIH2 is an inositol pyrophosphate synthase that regulates arbuscular mycorrhiza
Kiran Raj, Verena Gaugler, Mengsi Lu, Maren SchÀdel, Philipp Gaugler, Charlotte M. M. Grothaus, Ulrike A. Jochimsen, Athanasios Makris, Simon M. Bartsch, Anna M. Frentzen, Guizhen Liu, Michael Harings, Dorothea Fiedler, Henning J. Jessen, Gabriel Schaaf, Martina K. Ried-Lasi
Multicellular senescence impairs skeletal muscle recovery following disuse in aging
Paul-Emile Bourrant, Elena M. Yee, Zachary J. Fennel, Robert J. Castro, Chad M. Skiles, Jonathan J. Petrocelli, Naomi M. M. P. de Hart, Lisa A. Lesniewski, Anna E. Beaudin, Katsuhiko Funai, Christopher S. Fry, Micah J. Drummond
Tumor-targeted bispecific antibodies effectively inhibit oncogenic pathways while minimizing toxicity
Yvonne T. Kschonsak, Wei-Ching Liang, Joyce Chan, David Kan, Thao Nguyen, Karen Ruiz, Yee-Seir Kee, Wen-Ting K. Tsai, Hongkang Xi, Marina Moskalenko, Travis Morgenstern, Aurelie Herault, Lauriane Cabon, Ryo Okuda, Scott S. Stawicki, Jocelyn Chan, Matthew Grimmer, Diego Ellerman, James Mondo, Catherine F. Ruff, Gabriele Schaefer, Udi Segal, Robert Piskol, Nicholas J. Agard, Laetitia Comps-Agrar, Felipe de Sousa e Melo, James T. Koerber
Noncanonical PI(4,5)P 2 coordinates lysosome positioning through cholesterol trafficking
Ryan M. Loughran, Gurpreet K. Arora, Jiachen Sun, Alicia Llorente, Sophia Crabtree, Cynthia Y. Zhang, Kyanh Ly, Ren-Li Huynh, Wonhwa Cho, Brooke M. Emerling
A miniaturized implantable electrochemical platform for continuous monitoring of metabolites in deep tissue
Kenneth E. Madsen, Dane Hintermueller, Elliot A. Opel, Joseph G. Ribaudo, Sara Saffari, Soongwon Cho, Joanna L. Ciatti, Yu-Ting Huang, Amanda M. Westman, Ralph G. Nuzzo, Mitchell A. Pet, John A. Rogers
State-specific inhibition of NMDA receptors by memantine provides insight into NMDAR channel blocker tolerability
Matthew B. Phillips, Nadya V. Povysheva, Elizabeth G. Neureiter, Aparna Nigam, Karen A. Harnett-Scott, Johannes W. Hell, Elias Aizenman, Jon W. Johnson
Developmental candidate GHP-88310/EIDD-3608 with high tolerability and oral efficacy in measles and respiratory paramyxovirus models
Carolin M. Lieber, Josef D. Wolf, Mugunthan Govindarajan, Jeong-Joong Yoon, Zachary M. Sticher, Claire E. Ruckel, Alexander I. Leach, Lauren A. Harrison, Dariia Vyshenska, Amalia A. Cruz, Meghan K. Andrews, Rebecca E. Krueger, Robert M. Cox, George R. Painter, Alexander L. Greninger, Michael G. Natchus, Richard K. Plemper
Structurally engineered ultrasoft PEDOT:PSS fiber microelectrodes with enhanced electrochemical performance for neural interfaces
Chihyeong Won, Young Uk Cho, Siyeon Kweon, Sungjoon Cho, Chaebeen Kwon, Hyun Woo Kim, Ju Young Lee, Sang Hoon Park, Sorim Han, Yang Tae Kim, Jumyoung Jang, Janghwan Jekal, Jae Geun Kim, Kyung-In Jang, Sheng Xu, Wei Gao, Il-Joo Cho, Ki Jun Yu, Taeyoon Lee
Structural properties, polymorphism, and multiscale disorder unravel energy transport limitations in perylene diimide semiconductors
Christopher J. H. Smalley, Colan E. Hughes, Tom Willhammar, Raj Pandya, Semion K. Saikin, Duncan N. Johnstone, Jeffrey Gorman, Jooyoung Sung, Gianni Jacucci, Paul A. Midgley, Demie M. Kepaptsoglou, Quentin M. Ramasse, Akshay Rao, Kenneth D. M. Harris, Sean M. Collins
Shifting IRES versus Cap-initiated translation during homeostatic stem cell differentiation and stress
Michael C. Mazzola, Ting Zhao, Anna Kiem, Trine A. Kristiansen, Karin Gustafsson, Lai Ping Wong, Emily Scott-Solomon, Marissa D. Fahlberg, Christina Mayerhofer, Ernst Mayerhofer, Sarah Forward, Emane Rose Assita, Giulia Schiroli, Maris Handley, Youmna Kfoury, Tsuyoshi Fukushima, Dan Li, Samuel Keyes, Azeem Sharda, Jelena Milosevic, Hiroki Kato, Pavel Ivanov, David B. Sykes, Sheldon J. J. Kwok, Ruslan I. Sadreyev, Vijay G. Sankaran, Ya-Chieh Hsu, David T. Scadden
Limited transmission of cervid prions to nonhuman primates provides insights into the zoonotic potential of chronic wasting disease
Samia Hannaoui, Sandra Pritzkow, Wiebke M. JĂŒrgens-Wemheuer, Dirk Motzkus, Joo-Hee WĂ€lzlein, Karla A. Schwenke, Yo-Ching Cheng, Hanaa Ahmed Hassan, Irina Zemlyankina, Kylee Drever, Michael Beekes, Walter J. Schulz-Schaeffer, Christiane Stahl-Hennig, Sabine Gilch, Claudio Soto, Stefanie Czub, Hermann M. SchĂ€tzl
A reanalysis of 100 studies examining which immigrants citizens prefer highlights why some immigrants are favored and what creates dichotomies of âgoodâ and âbadâ immigrants.
Which immigrants do citizens prefer? A meta-reanalysis of 100 conjoint experiments
Marco Aviña, Taeku Lee, Mashail Malik, Reed Rasband, Marcel F. Roman, Priyanka Sethy
In the past decade, an important literature in the social sciences has examined public attitudes toward immigrants in host societies. In it, a prominent experimental methodâthe conjoint design, where participants are tasked with rating or choosing between randomized profilesâhas been used reliably to understand how immigrant characteristics shape admission preferences. We collate replication datasets from 100 individual studies spanning 1,475,403 immigrant profiles with 26 randomized attributes evaluated by 142,817 survey respondents from 36 countries. Meta-analyses reinforce well-established findings: Economic, cultural, humanitarian, and procedural factors all influence evaluations. Meta-reanalyses show that preferences are broadly similar across countries and demographic groups. However, they also reveal two additional patterns: Economic considerations have become more influential over time, and evaluations of individual immigrants differ sharply depending on where people stand on the broader immigration debate. These findings shed light on ongoing debates and point to fruitful areas for future research.
A high-resolution, US-scale digital similar of interacting livestock, wild birds, and human ecosystems for multihost epidemic spread
Abhijin Adiga, Ayush Chopra, Mandy L. Wilson, S. S. Ravi, Dawen Xie, Samarth Swarup, Bryan L. Lewis, Andrew Scott Warren, John Barnes, Ramesh Raskar, Madhav V. Marathe
Ancient DNA from shells reveals delayed genomic erosion and rapid immune adaptation in the critically endangered black abalone
T. Brock Wooldridge, Joshua D. Kapp, Sarah M. Ford, William E. Seligmann, Holland C. Conwell, Talia Tzadikario, Jonas Oppenheimer, Zachary G. Anderson, Alan Le Moan, Alicia AbadĂa-Cardoso, Peter Raimondi, Beth Shapiro
Chemical modulation of chloroplast de- and redifferentiation reveals a role for the SAL1âPAP retrograde pathway in facilitating plastid transitions
Pablo Perez-Colao, Jacobo Cruces, Santiago Perez-Rodriguez, Anna Koprivova, Stanislav Kopriva, Aleksandra Skirycz, Jorge Lozano-Juste, Manuel Rodriguez-Concepcion
A negative-hydrated constriction zone is revealed in the active state of the H v 1 channel
Juan J. Alvear-Arias, Dario Basaez, Emerson M. Carmona, Luciano Galizia, Miguel Fernandez, Antonio Peña-Pichicoi, Marcelo Ozu, Orlando Jorquera, Ramón Latorre, Alan Neely, Jose Antonio Garate, Carlos Gonzalez
Multiple defects in macrophage antibacterial responses support intracellular survival of Mycobacterium abscessus in cystic fibrosis
Abdullah A. Tarique, Stefan Emming, Dean Kelk, Jayden Logan, Divya Ramanth, Emma K. Dalton, Kaustav Das Gupta, Tamara Blake, James E. B. Curson, Syeda Farhana Afroz, Matthew J. Sweet, Claire E. Wainwright, Ronan Kapetanovic, Laurent Kremer, Scott C. Bell, Emmanuelle Fantino, Peter D. Sly
Impact of sex chromosomes and gonad type in stress susceptibility in corticostriatal brain regions
Kelly N. Barko, Micah A. Shelton, Dawson R. Kropp, Thien Quy Pham, Jennifer R. Rainville, Xiangning Xue, George C. Tseng, Georgia E. Hodes, Marianne L. Seney
Long-term antibody dynamics challenge the paradigm of lifelong homotypic immunity to dengue virus
Jair Andrade, Adrien Mitard de Girardier, Angkana T. Huang, Darunee Buddhari, Marco Hamins-Puertolas, Maria-Theresa Alera, Mary Noreen Chua, Taweewun Hunsawong, Derek A. T. Cummings, Stephen Thomas, Heather Friberg, Jeffrey R. Currier, Adam Waickman, Aaron Farmer, In-Kyu Yoon, Kathryn Anderson, Alan L. Rothman, Henrik Salje
EpsteinâBarr virus (EBV) infection causes human germinal center B cellâderived lymphomas in the absence of EBNA2 expression
Chunyan Wang, Jillian A. Bristol, Scott E. Nelson, Tony Chen, Charlotte Hendrickson, Dana C. Baiu, Mariah Riel, Mitch Hayes, Erik A. Ranheim, Jenny E. Gumperz, Eric C. Johannsen, Shannon C. Kenney
Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells
Andrew L. Sabol, Amanuella A. Mengiste, Prashant Singh, Vedagopuram Sreekanth, Samuel J. Hendel, Minh Thuan Nguyen Tran, Anton M. Barybin, Santosh Chaudhary, RaâMal M. Harris, Kristi E. Liivak, Zachary C. Severance, Cale M. Locicero, Karishma Kailass, Chaiheon Lee, Lucy Qinghua Xu, Vincent L. Butty, Amit Choudhary, Matthew D. Shoulders
Social interactions in isolated, confined, and extreme environments: A study of Antarctic winter teams using wearable sensors
Andrea Cantisani, Jan B. Schmutz, Pedro Marques-Quinteiro, Lorenzo DallâAmico, Ciro Cattuto, Mirko Antino, Walter J. Eppich, Katharina Stegmayer, Sebastian Walther
Dynamic compression of whole-brain neural trajectories during human motor learning
Hoora Mohseni, Ali Rezaei, Maryam Ansari Esfeh, Corson N. Areshenkoff, Daniel J. Gale, Joseph Y. Nashed, Emily R. Oby, Juan Chen, Jeffrey D. Wammes, Douglas J. Cook, Jason P. Gallivan
Plants tolerate substantial rates of plastid mistranslation via regulated proteostasis
Benjamin Brandt, Sebastian Schwartz, Serena Schwenkert, Moritz KrĂ€mer, Kuenzang Om, Carina Engstler, Andreas Klingl, Peter Jahns, Etienne H. Meyer, Rachael A. DeTar, JĂŒrgen Eirich, Iris Finkemeier, Asaph B. Cousins, Hans-Henning Kunz
Atomic layer-deposited nucleation layers to control zinc morphology and suppress hydrogen evolution
Ajay Ravi, Sanzeeda Baig Shuchi, Guangxia Feng, Yuqi Li, Pu Zhang, Junyan Li, Tzu-Ling Liu, Giulio DâAcunto, Angela Cai, Tony Li, Kenzie M. Sanroman Gutierrez, Zaichun Liu, Jing Wang, Ge Zhang, Jun Ho Lee, Junyoung Lee, Xueer Xu, Xun Guan, Xueli Zheng, Stacey F. Bent, Yi Cui
Oxidative stress and serum deprivation influence the evolution of newly formed tetraploid cells during tumorigenesis
Megan L. Sweet, Mathew Bloomfield, Nicholas Keen, Nazia Bano, Xiang Pan, Nicolaas C. Baudoin, Barath Udayasuryan, Raffae N. Ahmad, Eva Riddervold, Erica Klaiber, Scott S. Verbridge, Eva M. Schmelz, Jing Chen, Daniela Cimini
Electrical stimulation promotes longevity and regeneration in a colonial chordate
Jos Domen, Yotam Voskoboynik, Tom Levy, Erica M. Domen, Katherine J. Ishizuka, Karla J. Palmeri, Chiara Anselmi, Thomas Rolander, Norma F. Neff, Angela M. Detweiler, Irving L. Weissman, Kimberly L. Gandy, Debashis Sahoo, Ayelet Voskoboynik
Ultraslow conformational dynamics and catch bond formation of a bacterial adhesin revealed by a single-domain variant of FimH
Pearl Magala, Lisa M. Tuttle, Gianluca Interlandi, Laura A. Carlucci, Molly Y. Mollica, Maria K. Janowska, Wendy E. Thomas, Evgeni V. Sokurenko, Rachel E. Klevit
Uncovering ParB-dependent and -independent subclasses of T-dioxygenases from bacteriophage
Katherine H. OâToole, Lydia J. Perkins, Auriane Bouchet, Mia L. DeSanctis, Sean R. Lund, Andrew J. Mulholland, Yahya El Hariri, Sabaa Belkadi, Harold W. Bell, David M. Hough, Lana Saleh
Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo
Xuexiang Han, Ying Xu, Adele S. Ricciardi, Junchao Xu, Yan Xiang, Rohan Palanki, Vivek Chowdhary, Lulu Xue, Ningqiang Gong, Mohamad-Gabriel Alameh, William H. Peranteau, James M. Wilson, Daniel Reker, Drew Weissman, Michael J. Mitchell
AI assists adversarial collaboration in debate on minority salience
Barbara Mellers, Leo Yuan, Yubo Zhou, Isabelle Mauboussin, Eyana C. Lao, Bea Corio, Ville Satopaa, Lyle Ungar, Sudeep Bhatia, Cory J. Clark, Rasha Kardosh, Ran Hassin, Asael Sklar, Surya Gayet, Chris Paffen, Stefan Van der Stigchel, Andre Sahakian, Philip Tetlock
Genome-wide association mapping and targeted loss of function studies identify Shroom3 as a driver of hyperpolyploidy and ventricular dilation
Alexandra L. Purdy, Amirala Bakhshian Nik, Anooj A. Arkatkar, Prottoy Hasan, Michael A. Flinn, Priyanka Choudhury, Cheyret Wood, Akiko Takizawa, Lynn Malloy, Monika Tutaj, Thomas A. Drysdale, Darren Bridgewater, Brian A. Link, Timothy F. Plageman, Anne E. Kwitek, Melinda R. Dwinell, Laura M. Saba, Caitlin C. OâMeara, Michaela Patterson
Aging increases the cortical resources allocated to static balance maintenance
Thomas Legrand, Scott J. Mongold, Laure MĂŒller, Maxime Niesen, Zoritsa Demerdziev, Pierre Coemelck, Esranur Yildiran Carlak, Antonella Iannotta, Gilles Naeije, Mathieu Bourguignon, Marc Vander Ghinst
Our cognitive processes are largely shaped by what is present in our environment, while absences are often overlooked. This fundamental tendency of the human mind can lead to a significant social bias: individuals frequently fail to notice the absence of minority groups, even in situations where that absence is meaningful and consequential (e.g., educational settings, workplaces). In three preregistered field studies conducted across two cultures, we found robust evidence for blindness to minority absence. Our findings reveal that this blindness can persist for years, even among individuals who, once the absence is pointed out, acknowledge its significance and the need to address it. Eight preregistered laboratory experiments confirm that people are unlikely to detect the absence of a minority group. As our results indicate, people are more likely to notice the presence of a single minority member than the groupâs complete absence. In contrast, the absence of majority group members is far more noticeable. These patterns emerge even when monetary incentives for accuracy are introduced, regardless of participantsâ ideologies or social attitudes, and are evident even among individuals from minority groups. The final experiment suggests that highlighting an overlooked minority absence leads to higher stated support for diversity-promoting policies. Taken together, our findings suggest that basic cognitive constraints bias what people spontaneously notice in social environments: minority absences often go unnoticed, while majority absences and minority presences are more readily perceived. We propose that this bias may present a significant barrier to fostering inclusive social environments.
Chinaâs one-child policy amplifies intergenerational inequality via enlarged differential fertility
Using the staggered rollout of Chinaâs one-child policy (OCP) across provinces and birth cohorts as a quasi-natural experiment, we demonstrate that differential fertility between richer and poorer households exacerbates intergenerational income inequality. Rural/poorer families, who are less constrained by the OCP than their urban/richer counterparts, tend to have more children but invest less in each childâs human capital. This reduction in mobility is primarily driven by the rising economic status of children born to urban/wealthier families. Our estimates suggest that the OCP accounts for approximately 25% of the observed decline in intergenerational income mobility in China and thus highlight a demographic channel through which economic inequality persists across generations.
Semantic knowledge guides innovation and drives cultural evolution
Cultural evolution allows ideas and technologies to accumulate across generations, reaching their most complex and open-ended form in humans. While social learning enables the transmission of such innovations, the cognitive processes that generate them remain poorly understood. Classical theories typically treat innovation as random variation, a simplification insufficient for explaining the complexity of human cultural evolution. We propose that semantic knowledgeâthe associations linking concepts to their properties and functionsâguides human innovation and drives cumulative culture. To test this, we combined an agent-based model, which examines how semantic knowledge shapes cultural evolutionary dynamics, with a large-scale behavioral experiment (N = 1,243) testing its role in human innovation. Across both approaches, we found that semantic knowledge directed exploration toward meaningful solutions, enhanced innovation success, and enabled generalization from prior discoveries. Moreover, semantic knowledge interacted synergistically with social learning to amplify innovation and accelerate cumulative cultural change. In contrast, experimental participants lacking access to semantic knowledge performed no better than chance, even when social learning was possible, and relied on shallow exploration strategies for innovation. Together, these findings suggest that semantic knowledge is a key cognitive process underpinning human cumulative culture.
AI-assisted teams outperform AI-led teams but not human-only teams in assessing research reproducibility in quantitative social science
Large Language Models (LLMs) such as ChatGPT are transforming how scientists conduct and validate research, offering promise as tools to improve scientific reproducibility. However, computational reproducibility and error detection remain expensive and labor-intensive. We experimentally test how collaboration between researchers and LLM assistants influences the reproduction of quantitative social science findings across different levels of AI autonomy. We randomly assigned 288 researchers to 103 teams working under three conditions: human-only, AI-assisted (using ChatGPT as a collaborative tool), or AI-led (ChatGPT operating with minimal human oversight). Teams reproduced published results from leading social science journals, detected coding errors, and proposed robustness checks. Human-only and AI-assisted teams achieved comparable reproduction rates (94% vs. 91%) and performed similarly on most outcomes, except human-only teams identified significantly more major coding errors. Both substantially outperformed AI-led teams, which achieved only a 37% reproduction rate, detected fewer errors across all categories, proposed weaker robustness checks, and required more time. This autonomous approach, however, likely represents only a lower bound of AI capabilities. Despite rapid model advances, expert human judgment currently remains indispensable for reliable empirical verification. While AI assistance did not degrade most outcomes, it provided no measurable advantages and was associated with reduced detection of major errors. However, the 37% autonomous reproduction rate indicates that AI could provide value in settings where scale or cost constraints preclude human review of papers, even though general-purpose LLMs offer no immediate advantages for human-supervised verification.
Peer influence on West Point cadetsâ Civil War allegiances
Do social networks and peer influence shape major life decisions in polarized settings? We explore this question by examining how peers influenced the allegiances of West Point cadets during the American Civil War. Leveraging quasi-random variations in the proportion of cadets from Free States, we analyze how cadetsâ decisions about which army to join depended on the composition of their peers. We have three main findings. First, there was a strong and significant peer effect: a higher proportion of classmates from Free States significantly increased the likelihood that cadets from Slave States joined the Union Army. Second, the peer effect varies with geography, most notably with the slave population share in cadetsâ home states or counties, and with cadetsâ own slave ownership in 1860. Third, peer effects were amplified by shared experiences such as having served together in the Mexican-American War, continuous military service, and belonging to the same cohort, suggesting that sustained interaction is important.
Scientific Data
GPT-4o mini: Non-social science research article
A concordance between patent and trademark classes to link technologies to markets
Cataract-LMM Large-Scale Multi-Source Multi-Task Benchmark for Deep Learning in Surgical Video Analysis
Mohammad Javad Ahmadi, Iman Gandomi, Parisa Abdi, Seyed-Farzad Mohammadi, Amirhossein Taslimi, Mehdi Khodaparast, Hassan Hashemi, Mahdi Tavakoli, Hamid D. Taghirad
A Multi-center Gadolinium-ethoxybenzyl-diethylenetriamine Pentaacetic Acid (Gd-EOB-DTPA) MRI Dataset with Expert Annotations and clinicopathological data
Older patients who are acutely ill are a vulnerable group who are often excluded from scientific research. Nevertheless, psychosocial and health-related changes pose a particular challenge for this group that must be understood as our society continues to age. Geriatric syndromes, which are disease-unspecific, may particularly affect disease management and well-being. This dataset contains longitudinal data on 666 geriatric patients recruited from geriatric wards and outpatient practices. At baseline, routine data containing geriatric assessments (evaluating cognition, mood, mobility, daily activities, nutrition) and medical information were collected, as well as data from questionnaires regarding demographics, geriatric syndromes, self-management, loneliness, quality of life (WHOQOL-Bref), self-efficacy and attitudes towards ageing. During telephone follow-ups after three and six months, survival was recorded, as well as changes in health, geriatric syndromes and healthcare usage. Measures of quality of life, self-management and views on ageing were repeated. The dataset can be used for a variety of analyses investigating the personal, social and institutional factors that influence health and well-being in older patients.
Socio-Economic Review
Old and new welfare states retaining older workers in the face of crisis: the case of COVID-19 in Europe
The Coronavirus pandemic was a unique crisis in Europe as an unprecedented health and labour market shock barely disrupted long-term trends towards active ageing. We study the role of social policy responses and pre-existing welfare state institutions in moderating older workersâ early exit following the crisis. Using a cross-nationally harmonized panel survey in Europe, we examine whether variations in national labour market policies and pension institutions explain older workersâ exit outcomes following COVID-19, net of the economic shock and pre-pandemic employment levels. Results show that, across countries, the rollout of novel job retention schemes was consistently associated with the retention of older workers, whereas extended unemployment insurance likely had a limited influence. Higher retirement ages and greater reliance on private pensions were modestly associated with lower exit rates only among low-educated workers. Our findings confirm the significance of welfare states managing the crisis-driven economic shock and offer policy implications.
The lasting impact of crisis narratives: explaining social democratic austerity in Sweden
While research on policymaking during economic crises highlights the role of narratives for policy responses, few studies have examined the impact of crisis narratives after measures to avert the crisis have been implemented. This study addresses this research gap, presenting a case study of the Social Democratic Party of Sweden, which has remained committed to austere fiscal rules over the past three decades. Analyzing its economic policymaking, I argue that the partyâs narrative legitimation of the fiscal consolidation programme, designed as a response to the recession of the early 1990s, is central to understanding the partyâs enduring commitment to fiscal austerity. Reproducing this narrative has increased the political cost of reorientation and prevented alternative policies from being considered. Theoretically, these arguments demonstrate that narratives of economic crisis can operate as positive feedback mechanisms long after the narrated events have passed.